来氟米特联合激素治疗难治性肾病综合征效果分析

开篇：润墨网以专业的文秘视角，为您筛选了一篇来氟米特联合激素治疗难治性肾病综合征效果分析范文，如需获取更多写作素材，在线客服老师一对一协助。欢迎您的阅读与分享！

DOI：10.16662/ki.1674-0742.2017.11.145

[摘要] 目的 分析用来氟米特联合激素治疗的方法，在针对性治疗难治性肾病综合征患者时进行临床效果观察。方法方便选取2013年11月―2015年10月该医院就诊的84例难治性肾病综合征患者为研究对象，根据治疗方法的不同，将患者随机分组，采用来氟米特联合激素（醋酸泼尼松）治疗的患者为“治疗组”；采用环磷酰胺联合激素治疗的为“对照组”，每组42例。将两组患者的血白蛋白、血肌酐、24 h尿蛋白定量等相关指标水平在治疗前和治疗后4个月所发生的变化进行对比，同时分析两种不同治疗方法的治疗效果。结果 治疗组、对照组患者经治疗后病情均有好转，治疗组尿蛋白定量水平为（2.5±0.5）g/24 h，血白蛋白水平为（32.7±3.8）g/L，血肌酐水平为（72.4±7.8）μmol/L；治疗组、对照组的治疗总有效率分别为92.8%、69.0%，治疗组患者的治疗效果相比对照组明显要好，差异有统计学意义（P

[关键词] 来氟米特；激素；联合治疗；难治性肾病综合征；效果分析

[中图分类号] R692.3 [文献标识码] A [文章编号] 1674-0742（2017）04（b）-0145-03

Analysis of General Effect of Leflunomide and Hormone in Treatment of Refractory Nephrotic Syndrome

ZHOU Chun-yan， LIANG Shao-ming

Department of Nephrology， Rongchen People’s Hospital， Rongcheng， Shandong Province， 264300 China

[Abstract] Objective To analyze the clinical effect of leflunomide and hormone in treatment of refractory nephrotic syndrome. Methods 84 cases of patients with refractory nephrotic syndrome diagnosed in our hospital from November 2013 to October 2015 were selected and randomly divided into two groups with 42 cases in each according to different treatment methods， the treatment group were treated with leflunomide and hormone （prednisone acetate）， the control group were treated with cyclophosphamide and hormone， and the changes of blood albumin， serum creatinine and 24 h urine protein before treatment and in 4 months after treatment were compared， at the same time， the treatment effect of the different methods was analyzed. Results After treatment， the disease conditions of the two groups were improved， and the urine protein level， blood albumin and serum creatinine in the treatment group were respectively （2.5±0.5）g/24 h， （32.7±3.8）g/L and （72.4±7.8）μmol/L， and the total effective rate in the treatment group and in the control group was respectively 92.8% and 69.0%， and the treatment effect in the treatment group was obviously better than that in the control group， and the difference was statistically significant（P

[Key words] Leflunomide； Hormone； Refractory nephrotic syndrome； Analysis of effect

I病综合征作为常见肾脏疾病的一种，致病因素多样，主要原因是肾小球发生病变，常以滤过率降低、肾小球基底膜通透性增加等为主要体现[1-2]。来氟米特主要由嘧啶合成的一种新型的免疫抑制剂，在治疗难治性肾病综合征和狼疮肾炎方面疗效确切，可有效防止传统治疗上的欠缺[3-4]。该研究方便选取2013年11月―2015年10月该医院治疗的84例难治性肾病综合征患者为研究对象，将其分两组，分别给予来氟米特联合激素治疗和环磷酰胺联合激素治疗的治疗，并将其临床疗效进行统计对比，现报道如下。