尼莫地平对高血压脑出血患者脑血肿、水肿及神经功能恢复的影响

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[摘要] 目的 探讨尼莫地平对高血压脑出血患者血肿、水肿及神经功能恢复的影响。 方法 选择我院2013年1～12月收治的高血压脑出血患者84例，随机分为研究组和对照组，各42例，对照组患者给予传统脱水、止血、抗炎、降压治疗，研究组患者在对照组治疗的基础上给予尼莫地平治疗；全部患者治疗3周后进行CT检查，观察血肿及周围水肿带体积变化情况，比较治疗前后神经功能缺损评分改善情况，评价治疗效果。 结果 治疗后两组血肿体积、水肿体积较治疗前减小，神经功能缺损评分较治疗前降低，前后差异有统计学意义（P

[关键词] 高血压脑出血；尼莫地平；血肿；水肿；神经功能缺损评分

[中图分类号] R743.34 [文献标识码] B [文章编号] 2095-0616（2015）01-121-03

[Abstract] Objective To investigate the influence of Nimodipine on restoration of cerebral haematoma，edema and neurological function of patients with hypertensive cerebral hemorrhage. Methods 84 case of patients with hypertensive cerebral hemorrhage in our hospital from January to December 2013 were randomly divided into research group and control group，42 cases in the control group were given conventional dehydration，hemostasis，anti-inflammatory，antihypertensive treatment，research group was given nimodipine treatment on the basis of control group.After three weeks treatment，all patients were given CT scan，cerebral haematoma and edema volume changes were observed，before and after treatment，neurological deficit scores were compared，and therapeutic effect of two groups were evaluated. Results After treatment，hematoma，edema volume and neurological deficit scores of two groups were decreased，the differences were significant（P

[Key words] Hypertensive intracerebral hemorrhage；Nimodipine；Hematoma；Edema；Neurological function

高血压脑出血是临床常见的急性脑血管疾病，约占自发性脑出血性疾病的60%～70%，致死致残率高。脑出血患者中血肿占位引起的机械性压迫、周围水肿、脑组织缺血、以及出血引起的生化反应是病理损伤的基础，是导致患者神经功能缺失的主要原因[1]。目前临床对于高血压脑出血量较少的患者（30mL以内）多采用保守治疗，而有研究表明钙离子拮抗剂能够减轻血管痉挛、减少局部脑组织继发性出血、清除自由基，这对患者血肿消除、神经功能恢复有重要作用[2-3]。本文选择本院高血压脑出血保守治疗患者，治疗中加用尼莫地平，探讨其对血肿、水肿及神经功能的影响。

1 资料与方法

1.1 一般资料

选择本院2013年1～12月收治的高血压脑出血患者84例。入组标准：患者发病时间