产前筛查中孕中期孕妇uE3、AFP和Freeβ―HCG检测及超声的应用价值

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【摘要】 目的 著重于探讨甲胎蛋白（AFP）、游离雌三醇（uE3）和游离人绒毛促性腺激素β亚单位（Freeβ-HCG）检测及超声在孕中期孕妇产前筛查中的应用价值。方法 对3500例产检孕中期的孕妇进行研究， 给予产前AFP、ue3与Freeβ-HCG检测联合超声诊断， 分析诊断效果与价值。结果 3500例孕中期孕妇查出高风险孕妇152例， 约占4.34%（152/3500）， 高风险孕妇包括24例（15.79%）18三体高风险， 114例（75.00%）唐氏综合征高风险， 14例（9.21%）神经管缺陷高风险；查出低风险孕妇3348例， 约占96.66%。经产前诊断发现2例（0.06%）神经管缺陷， 3例（0.09%）唐氏综合征， 1例（0.03%）18三体；对不符合分娩要求者终止妊娠。在超声胎盘异常诊断中， 高风险孕妇胎盘异常率21.05%（32/152）， 低风险孕妇的胎盘异常率为3.17%（106/3348）， 两者胎盘异常率比较差异具有统计学意义（P

【关键词】 血清甲胎蛋白；游离人绒毛促性腺激素β亚单位；游离雌三醇；超声；孕中期；应用价值

DOI：10.14163/ki.11-5547/r.2017.09.007

Application value of uE3， afp and freeβ-hcg detection and ultrasound for pregnant metaphase women in prenatal screening LIANG Hua-ming， LI Jin-mei， CHEN Yue-mei. Department of Laboratory Medicine， Guangdong Yunfu City Xinxing County Maternal and Child Health Family Planning Service Center， Yunfu 527400， China

【Abstract】 Objective To mainly investigate application value of alpha fetoprotein （AFP）， uncojugated estriol （uE3） and free human chorionic gonadotropin β sigmasubunit （Freeβ-HCG） detection and ultrasound for pregnant metaphase women in prenatal screening. Methods A total of 3500 pregnant metaphase women in prenatal examination were taken into research， and they received prenatal AFP， uE3 and Freeβ-HCG detection combined with ultrasound for diagnosis. Analysis was made on diagnostic effect and value. Results Among the 3500 pregnant metaphase women， there were 152 high risk cases， accounting for 4.34% （152/3200）， including 24 cases （15.79%） with high risk of trisomy 18 syndrome， 114 cases （75.00%） with high risk of Down’s syndrome， and 14 cases （9.21%） with high risk of neural tube defects， and there were 3348 low risk cases， accounting for 96.66%. Prenatal diagnosis sowed 2 cases （0.06%） with neural tube defects， 3 cases （0.09%） with Down’s syndrome and 1 case （0.03%） with trisomy 18 syndrome. Termination of pregnancy was applied in unqualified patients. Diagnosis of placental abnormality by ultrasound showed placental abnormality rate in high risk pregnant women as 21.05% （32/152） and 3.17% （106/3348） in low risk pregnant women， and their difference of placental abnormality rate had statistical significance （P