灌肠联合苯巴比妥对母乳性黄疸患儿体液和细胞免疫功能的影响研究
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[摘要] 目的 研究灌肠联合苯巴比妥对母乳性黄疸患儿体液和细胞免疫功能的影响。 方法 选取2009年2月～2012年1月我院进行治疗的64例母乳性黄疸患儿为研究对象，根据随机数字表法将其分为灌肠组（对照组）和灌肠联合苯巴比妥组（观察组），每组各32例。将两组患儿治疗后3、7、10 d及10 d以上的黄疸消退率、治疗前后的体液和细胞免疫功能指标进行比较。 结果 观察组治疗后3、7、10 d的黄疸消退率明显高于对照组，而其治疗后3、7、10 d的体液和细胞免疫指标改善幅度也大于对照组，差异有统计学意义（P < 0.05）。 结论 灌肠联合苯巴比妥对母乳性黄疸患儿体液和细胞免疫功能的影响明显，可显著改善患儿的机体免疫力。
[关键词] 灌肠；苯巴比妥；母乳性黄疸；体液免疫；细胞免疫；影响
[中图分类号] R72 [文献标识码] A [文章编号] 1673-7210（2012）07（b）-0010-03
Study of the influence of enema combined with phenobarbital on humoral immunity and cellular immunity of children with breast milk jaundice
LI Longqing
Department of Neonatology, Hospital of Traditional Chinese Medicine of Pingquan County in Chengde City, Hebei Province, Pingquan 067500, China
[Abstract] Objective To study the influence of enema combined with phenobarbital on humoral immunity and cellular immunity of children with breast milk jaundice. Methods 64 cases of children with breast milk jaundice in our hospital from February 2009 to January 2012 were selected as research objects，and were divided into the control group (enema group) and the observation group (enema combined with phenobarbital group), each group had 32 cases according to random number table. The regression rate of jaundice after treatment at 3, 7, 10 d and more than 10 d, functional parameter of humoral immunity and cellular immunity before and after treatment were compared. Results In the observation group, the regression rates of jaundice after treatment at 3, 7, 10 d were all significantly higher than those of the control group; the improvement range of humoral immunity and cellular immunity parameters after treatment at 3, 7, 10 d were more than those of the control group, there were all significant differences (P ＜ 0.05). Conclusion The influence of enema combined with phenobarbital on humoral immunity and cellular immunity of children with breast milk jaundice is obvious, and it can significantly improve the body immunity of children.
[Key words] Enema; Phenobarbital; Breast milk jaundice; Humoral immunity; Cellular immunity; Influence
母乳性黄疸是指与母乳喂养有关的特发性黄疸，其在足月儿中较为多见，本病病因迄今尚未完全清楚，临床较多研究认为其与新生儿胆红素代谢的肠肝循环增加有关[1]，临床认为对于重症患者应给予治疗干预，以尽量降低其对神经系统的影响，临床中较为常用的干预方案为停母乳及其他干预等，而苯巴比妥也是临床应用较受肯定的药物之一。本文中笔者就灌肠联合苯巴比妥对母乳性黄疸患儿体液和细胞免疫功能的影响进行研究，具体情况总结分析如下：
1 资料与方法
1.1 一般资料
选取2009年2月～2012年1月于我院进行治疗的64例母乳性黄疸患儿为研究对象，根据随机数字表法将其分为灌肠组（对照组）和灌肠联合苯巴比妥组（观察组），每组各32例。对照组32例患儿中，男20例，女12例；日龄3.0～57.5 d，平均（18.8±3.7）d；出生体重3 012.5～4 615.5 g，平均（4 014.2±202.7）g；血清胆红素224.8～360.2 μmol/L，平均（305.4±22.6）μmol/L。观察组32例患儿中，男19例，女13例；日龄3.5～58.0 d，平均（18.9±3.5）d出生体重3 009.4～4 620.7 g，平均（4011.8±204.9）g血清胆红素225.7～362.4 μmol/L，平均（307.3±22.3）μmol/L。两组患儿的性别比、日龄出生体重、血清胆红素指标比较，差异无统计学意义（P > 0.05），具有可比性。本研究经医院伦理委员会通过，家属签署知情同意书。