脑胶质瘤术后调强放疗联合替莫唑胺化疗的疗效分析
开篇：润墨网以专业的文秘视角，为您筛选了一篇脑胶质瘤术后调强放疗联合替莫唑胺化疗的疗效分析范文，如需获取更多写作素材，在线客服老师一对一协助。欢迎您的阅读与分享！
[摘要] 目的 探讨脑胶质瘤术后调强放疗联合替莫唑胺化疗的临床效果。 方法 选取2009年2月～2011年3月我院收治的脑胶质瘤患者78例，随机平均分为两组，每组39例。术后均给予调强放疗，实验组在调强放疗的基础上使用替莫唑胺化疗。对比近、远期临床效果及不良反应。 结果 实验组调强放疗联合替莫唑胺化疗，有效率为64.1%，疾病控制率为92.3%。对照组有效率为38.5%，疾病控制率为74.4%。两组患者有效率和疾病控制率对比差异有统计学意义（P < 0.05）。实验组半年生存率为76.9%，一年生存率为64.1%；对照组半年生存率为59.0%，一年生存率为35.9%，两组对比均有显著差异（P < 0.05）。实验组不良反应稍高于对照组，但差异无统计学意义（P > 0.05）。 结论脑胶质瘤术后联合调强放疗和化疗具有协同效应，提高治疗效果，安全可靠，值得广泛推广。
[关键词] 脑胶质瘤；调强放疗；替莫唑胺
[中图分类号] R739.4 [文献标识码] C [文章编号] 1673-7210（2012）07（c）-0166-02
Analysis of curative effects of intensity modulated radiotherapy combined with Temozolomide chemotherapy after operation of cerebral glioma
HU Jiang PAN Jun LUO Zhiguo MING Bangchun
Taihe Hospital Affiliated Hospital of Hubei Medical College, Hubei Province, Shiyan 442000, China
[Abstract] Objective To investigate the clinical effects of intensity modulated radiotherapy combined with Temozolomide chemotherapy after operation of cerebral glioma. Methods A total of 78 patients with cerebral glioma admitted to our hospital from February 2009 to March 2011 were randomly divided into two groups. Both groups were given intensity modulated radiotherapy and the experiment group was given additional Temozolomide chemotherapy. Short-term and long-term clinical effects and adverse reactions were compared. Results In the experiment group, the effective rate was 64.1% and the disease control rate was 92.3%. In the control group, the effective rate was 38.5% and the disease control rate was 74.4%. The effective rates and the disease control rates were significantly different between the two groups (P < 0.05). In the experiment group, the six months survival rate was 76.9% and the one year survival rate was 64.1%, and in the control group, the six months survival rate was 59.0% and the one year survival rate was 35.9%, with significant differences in both rates between the two groups (P < 0.05). There were more adverse reactions in the experiment group than in the control group, with no significant difference (P > 0.05). Conclusion Intensity modulated radiotherapy combined with Temozolomide chemotherapy after cerebral glioma have synergistic effects, can improve curative effects, is safe and reliable, thereby worthy of wide promotion.
[Key words] Cerebral glioma; Intensity modulated radiotherapy; Temozolomide
脑胶质瘤（glioma）是发病率最高的脑部肿瘤，约占40%。发病年龄多在30～40岁。脑胶质瘤中以星形细胞瘤最多，其次为胶质细胞瘤和少枝胶质细胞瘤，其临床表现为头痛、恶心、复视、癫痫等[1]。因脑胶质瘤呈浸润性生长，且位于重要结构，单纯手术难以完全切除，术后易复发。临床上常规手术治疗后放疗以提高患者生存率，减少复发，但效果仍不理想。替莫唑胺是一种新型烷化剂-咪唑四嗪类衍生物，具有广谱抗肿瘤活性，生物利用度高[2]。本研究在脑胶质瘤术后采用调强放疗联合替莫唑胺化疗，效果较好，现报道如下：