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阿奇霉素治疗化脓性扁桃体炎的临床疗效探讨

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[摘要]目的 探讨并分析应用阿奇霉素治疗化脓性扁桃体炎患者的临床疗效。方法 选取该院收治的化脓性扁桃体炎患者112例,并随机分为两组,各56例。观察组、对照组分别给予患者阿奇霉素、青霉素钠进行治疗,对比分析其临床疗效。结果观察组患者经阿奇霉素治疗后的总有效治疗率为98.21%,对照组患者经青霉素钠治疗后的总有效治疗率85.71%,差异有统计学意义(χ2=4.35,P=0.037)。观察组患者的退热、咽部疼痛缓解、扁桃体红肿消失、脓栓消除时间低于对照组(t=8.288,P=0.000;t=10.179,P=0.000;t=16.034,P=0.000;t=14.595,P=0.000)。 结论 应用阿奇霉素治疗化脓性扁桃体炎患者,能够提高疗程结束后的治愈率,治疗效果更确切,改善患者临床症状迅速有效,值得推广。

[关键词] 化脓性扁桃体炎;阿奇霉素;青霉素钠;临床疗效

[中图分类号] R766.18 [文献标识码] A [文章编号] 1674-0742(2014)08(b)-0014-02

[Abstract] Objective To observe and analyze the clinical curative effect of azithromycin in the treatment of suppurative tonsillitis. Methods 112 patients with suppurative tonsillitis admitted in our hospital were selected and randomly divided into observation group and control group, 56 cases in each. The observation group and the control group patients were given azithromycin, penicillin sodium treatment, respectively, and the clinical efficacy of two groups were compared and analyzed. Results After treatment, the total effective rate of the observation group patients was 98.21%, while that of the control group patients was 85.71%, the difference was significant(χ2=4.35,P=0.037). The time to defervescence, throat pain relief time, swollen tonsil disappearing time and pus bolt elimination time of the observation group were less than that of the control group, respectively(t=8.288,P=0.000;t=10.179,P=0.000;t=16.034,P=0.000;t=14.595,P=0.000). Conclusion For patients with suppurative tonsillitis, Azithromycin can improve the cure rate with a precise treatment effect, and rapidly ameliorate the clinical symptoms, which is worthy of promotion.

[Key words] Suppurative tonsillitis; Azithromycin; Penicillin sodium; Clinical curative effect

化脓性扁桃体炎(Suppurative Tonsillitis)是临床上上呼吸道的一种常见的由A组β型溶血性链球菌感染导致的感染性疾病,发病机制较为复杂,起病急,病情进展迅速,严重时可出现心肌炎、风湿热、急性肾小球肾炎等严重并发症,后果严重[1]。因此,及时、正确的控制病情至关重要。目前临床上多使用青霉素钠(Penicillin Sodium)对化脓性扁桃体炎的患者进行治疗,效果并不理想。为了寻求一种更迅速、有效的治愈和改善化脓性扁桃体炎患者临床症状的药物,该研究选取2012年1月―2013年12月期间的112例化脓性扁桃体炎患者,分为两组,同时分别给予阿奇霉素(Azithromycin)和青霉素钠进行治疗,现报道如下。

1 资料与方法

1.1 一般资料

选取该院收治的化脓性扁桃体炎患者112例,患者就诊的主要原因包括发热、咽痛、全身疼痛、扁桃体红肿以及扁桃体表面脓性分泌物等,外周血中白细胞计数>10×109/L,中性粒细胞比值>60%,发病时间距离就诊时间

1.2 治疗方法

观察组:阿奇霉素(批准文号:国药准字H10970161)0.5 g+250 mL5%葡萄糖溶液,1次/d静脉滴注,疗程7 d;对照组:青霉素钠(批准文号:国药准字H23721440)250~300万U+100 mL0.9%氯化钠溶液,2次/d静脉滴注,疗程7 d。