大连地区798例正常成人尿氟结果探讨

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[摘要] 目的 建立大连地区尿氟正常值，为职业病诊断提供依据。 方法 采用国标方法离子选择电极法测定尿氟。选择2011年2～12月大连市内五区来我院进行召工体检，各项检查均正常，无氟接触史，年龄为21～53岁的正常人群共798名作为测定对象。 结果 798例尿氟检测结果经统计学分析显示，男女间差异无统计学意义（P > 0.05）；将市内五区分为两组，尿氟检测结果差异有统计学意义（P < 0.05），分别为0.91 mg/L（甘井子区与高新园区）、1.05 mg/L（中山区、西岗区和沙河口区），与总体1.0 mg/L差异不大；最终确定大连正常成人尿氟值在1.0 mg/L以下。 结论 大连地区尿氟正常值小于国家标准1.6 mg/L，在职业病筛查及诊断中应适当降低标准，以免漏检。

[关键词] 尿氟；正常值；离子选择电极法

[中图分类号] R446.122 [文献标识码] C [文章编号] 1673-7210（2012）07（b）-0113-02

Exploration of urinary fluoride results of 798 normalin Dalian area

SUN Dongjie GU Li WEI Wei

Department of Physical and Chemical Inspection, the Forth People's Hospital of Dalian City, Liaoning, Dalian 116001, China

[Abstract] Objective To establish the normal value of urinary fluoride, in order to provide basis for the diagnosis of occupational diseases. Methods The urinary fluoride was measured by the national standard method, namely ion selective electrode method. A total of 798 normal people without fluoride contact history from five districts in Dalian city aged from 21 to 53 years old, who received recruit physical examination in our hospital from February to December 2011 were selected. Results Statistical results of 798 people's urinary fluoride showed that there was no significant difference between male and female (P > 0.05); five districts in Dalian were divided into two groups, there was significant difference in urinary fluoride value between the two groups (P < 0.05), which were 0.91 mg/L and 1.05 mg/L respectively, but the two groups had no large difference from the overall 1.0 mg/L. The normal urinary fluoride value of adults in Dalian was below 1.0 mg/L. Conclusion The normal urinary fluoride value in Dalian is lower than the national standard of 1.6 mg/L, so the standard should be lowered properly in the screening and diagnosis of occupational diseases, in order to avoid omission.

[Key words] Urinary fluoride; Normal value; Ion selective electrode method

尿氟受很多因素影响[1-2]，群体尿氟水平能够反应氟的摄入、代谢和排泄情况。因此，在进行氟危害调查和评价防治效果时，用群体尿氟水平来分析氟的负荷状态很有价值[3-4]，但由于尿氟的影响因素很多，如与饮食、饮水、饮茶、活动量及采样时间等因素有非常密切的关系，导致尿氟的变化较大，因此，掌握本地健康人群的尿氟正常值范围有重要意义。而大连地区尿氟正常值范围尚未见有文献报道。本文采用离子选择电极法通过对798名正常体检人群尿氟的结果分析，以了解大连地区尿氟水平。

1 对象与方法

1.1 对象

选择2011年2～12月大连市内中山区、西岗区、沙河口区、甘井子区和高新园区5区来我院进行召工体检各项检查均正常、无氟接触史、年龄为21～53岁的正常人群798名作为测定对象，其中，女417名，男381名。

1.2 试剂与仪器

1.2.1 仪器

上海雷池仪器厂生产的PHS-2C型精密酸度计，恒温磁力搅拌器及配套的氟电极、甘汞电极等。

1.2.2 试剂

1.2.2.1 氟化物标准储备液 将氟化钠于105℃烘2 h，冷却至室温后准确称取0.221 g，溶于去离子水中并移于100 mL容量瓶中，定容至刻度，冰箱保存，此溶液1.00 mL含1.00 mg氟化物。