产前肾上腺皮质激素联合产后肺泡表面活性物质治疗新生儿呼吸窘迫综合征的临床疗效观察

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[摘要] 目的 观察产前肾上腺皮质激素联合产后肺泡表面活性物质治疗新生儿呼吸窘迫综合征的临床疗效。 方法 将本院收治的呼吸窘迫综合征患儿70例随机分为实验组与对照组，实验组37例患儿采用产前肾上腺皮质激素联合产后肺泡表面活性物质治疗，对照组33例患儿仅采用产后肺泡表面活性物质治疗。比较两组并发症发生率、死亡率、住院时间、机械通气时间以及呼吸机参数高浓度氧持续时间和最高MAP水平。 结果 实验组死亡率及并发症发生率都小于对照组（P < 0.05）；实验组住院时间和机械通气时间小于对照组（P < 0.05）；实验组呼吸机参数高浓度氧持续时间和最高MAP水平都小于对照组（P < 0.05）。 结论 产前肾上腺皮质激素联合产后肺泡表面活性物质治疗新生儿呼吸窘迫综合征临床疗效最显著，值得在临床推广应用。

[关键词] 肺泡表面活性物质；肾上腺皮质激素；新生儿呼吸窘迫综合征；临床疗效

[中图分类号] R722.1 [文献标识码] A [文章编号] 1674—4721（2012）09（c）—0073—02

Clinical efficacy observation of prenatal adrenal cortex hormone joint with postpartum pulmonary surfactant in treatment of neonatal respiratory distress syndrome

WU Qingping

Department of Pediatrics， Maternal and Child Health Hospital of Ji''an City in Jiangxi Province， Ji''an 343000， China

[Abstract] Objective To observe the clinical efficacy of prenatal adrenal cortex hormone joint with postpartum pulmonary surfactant in the treatment of neonatal respiratory distress syndrome. Methods Seventy cases of children with respiratory distress syndrome in our hospital were randomly divided into experimental group and control group， experimental group of 37 cases were treated with prenatal adrenal cortex hormone postpartum pulmonary surfactant treatment， and control group of 33 patients used onlypulmonary surfactant treatment. The two groups were compared the incidence of complications， mortality， hospital stay， duration of high concentrations of oxygen for the duration of mechanical ventilation and ventilator parameters， and the highest MAP level. Results The mortality and incidence of complications of experimental group was less than that of control group （P < 0.05）； hospitalization time and mechanical ventilation time of experimental group was less than that of control group （P < 0.05）； ventilator parameters of high concentrations of oxygen durationand and the highest MAP levels of experimental group were less than that of control group （P < 0.05）. Conclusion The clinical efficacy of prenatal adrenal cortex hormone joint with postpartum pulmonary surfactant in treatment of neonatal respiratory distress syndrome is the most significant. It is worthy of clinical application.

[Key words] Pulmonary surfactant； Adrenal cortex hormones； Neonatal respiratory distress syndrome； Clinical efficacy

新生儿呼吸窘迫综合征是因为缺乏肺泡表面活性物质而导致的呼吸困难及肺顺应性下降的呼吸系统疾病。虽然近来围生期医疗技术不断提高，但该病仍是新生儿重症监护室内新生儿死亡的首要因素[1]。为了评价产前肾上腺皮质激素联合产后肺泡表面活性物质治疗新生儿呼吸窘迫综合征的临床疗效，现对本院2010年12月～2012年3月收治的呼吸窘迫综合征患儿70例的完整临床资料进行回顾性分析，总结报道如下：