首页 > 范文大全 > 正文

早期子宫内膜癌最佳手术方式研究

开篇:润墨网以专业的文秘视角,为您筛选了一篇早期子宫内膜癌最佳手术方式研究范文,如需获取更多写作素材,在线客服老师一对一协助。欢迎您的阅读与分享!

【摘要】目的:探讨治疗早期子宫内膜最佳手术方式。方法:选取本院2008年1月-2012年1月收治的确诊为患有I~II期子宫内膜癌的178例患者,对其治疗资料进行回顾性分析,所有的患者均在初发时就诊,并都进行手术治疗,且在手术前都没有进行过化疗、放疗以及激素等方式治疗。根据国际标准对患者进行分期,根据治疗方式的不同,手术的方式分为3种,一为全子宫切除术,二为次广泛或者广泛性的子宫切除术,三为施行一或二,并且在同期施行盆腔淋巴结的切除术。然后比较各种手术方式的临床效果,总结出最佳的手术方式。结果:对于Ia期的患者行术式1、术式2、术式3在生存率方面比较差异无统计学意义(P>0.05),对于Ib期的患者,术式2、术式3和术式1相比,在5年生存率上明显要高,而术式2和术式3间比较无差异,对于Ic期和II期的患者,术式3的3年以及5年的生存率都最高。结论:对于子宫内膜癌应根据临床的分期,选择合适的手术方式,这是保证手术治疗效果以及患者预后的关键。

【关键词】早期子宫内膜癌;手术方式;临床疗效

Study on the Best Surgical Procedure for Early Endometrial Cancer/YANG Li.//Medical Innocation of China,2013,10(20):029-030

【Abstract】Objective:To investigate the best surgical approach to the treatment of early stage endometrial cancer. Method:Selecting 178 patients admitted by our hospital from January 2008 to 2012 January and diagnosed as stage I-II of endometrial cancer and the clinical data of the patients were analyzed retrospectively.All of the patients were staging with international standard,and than received surgery in the incipience with no way of chemotherapy, radiotherapy and hormone therapy before surgery.According to different surgical method, the operations were divided into three types: the first one was total hysterectomy;the second one was subtotal or extensive hysterectomy; the third one was performed in the base of the first or the second one combined with pelvic lymph node resection in the same paring the clinical effects of various surgical methods and than identified the best surgical procedures for diffirent stage of endometrial cancer. Result:There was no significant difference in three- year survival rate of Ia patients underwent these three surgical procedures (P>0.05).The five-year survival rate of Ib patients underwent surgical procedure of type two and three were significantly higher than that of type one,however, there was no significant difference between type two and three. for Ic and Phase II patients, The 3-year and 5-year survival rates of type three were the highest. Conclusion:According to clinical stage of endometrial cancer to choose an appropriate surgical a pproach ,which is the key to ensure the therapeutic effect and the prognosis of surgery.

【Key words】Early endometrial cancer;Optimal surgical approach;Clinical efficacy

First-author’s address: The First People’s Hospital of Chenzhou,Chenzhou 423000,China

doi:10.3969/j.issn.1674-4985.2013.20.014

子宫内膜癌(Endometrial Carcinoma)是发生于子宫内膜的一组上皮性恶性肿瘤,好发于围绝经期和绝经后女性,是最常见的女性生殖系统肿瘤之一[1-2],每年有接近20万的新发病例,在导致死亡的妇科恶性肿瘤中位列第三(仅次于卵巢癌和宫颈癌)。其发病与生活方式密切相关,发病率在各地区有差异[3],在北美和欧洲其发生率仅次于乳腺癌、肺癌、结直肠肿瘤,高居女性生殖系统癌症的首位。在我国,随着社会的发展和经济条件的改善,子宫内膜癌的发病率亦逐年升高,仅次于宫颈癌,居女性生殖系统恶性肿瘤的第二位[4]。 近几年,对于子宫内膜癌的研究方面有了很大的进展,不管在分子生物学研究方面还是各期子宫内膜癌的治疗方案上,都进行了深入的研究,这些研究成果为各期子宫内膜癌的诊断和治疗提供了非常宝贵的科学依据。临床上对于子宫内膜癌的治疗,以手术治疗为主,然后辅以化疗、放疗以及激素治疗手段[5-6]。本文选择本院2008年1月-2012年1月收治的确诊为患有I~II期子宫内膜癌的178例患者为研究对象,对其临床资料进行回顾性分析,分析不同时期不同手术方式的治疗效果,现将结果报道如下。

1资料与方法

1.1一般资料选取本院2008年1月-2012年1月期间收治的确诊为患有I~II期子宫内膜癌的178例患者。患者年龄24~68岁,平均年龄(38.26±4.18)岁,且178例患者都符合早期子宫内膜癌的纳入标准:都为手术治疗的患者;术前及术后的病理组织学检查诊断结果明确;属于子宫内膜癌I~II期患者;术后的随访可靠。按照国际-FIGO制定的分期标准对患者进行分期,其中I期患者共136例,Ia期48例,Ib期64例,Ic期24例;II期患者42例。