血清降钙素原在肺结核抗结核治疗疗效评估中的价值

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[摘要] 目的 研究血清降钙素原在肺结核抗结核治疗疗效评估中的价值。 方法 选择2012年1月～2013年1月本科诊治的肺结核患者为研究对象（观察组），以同期未行抗结核治疗的肺结核患者为对照（对照组），比较两组患者治疗前后血清降钙素原的水平并分析不同水平降钙素原抗结核治疗疗效差异。 结果 观察组和对照组肺结核患者治疗前血清降钙素原差异无统计学意义，观察组患者治疗后1个月、3个月和6个月血清降钙素原显著降低（P

[关键词] 肺结核；降钙素原；疗效

[中图分类号] R521 [文献标识码] B [文章编号] 2095-0616（2013）15-152-02

Value of serum procalcitonin in anti-tuberculosis therapeutic effect evaluation for tuberculosis

XU Li JIN Xue

Department of Infectious Disease， the No.1 People's Hospital of Guangshui， Guangshui 432700， China

[Abstract] Objective To study the value of serum procalcitonin in anti-tuberculosis therapeutic effect evaluation for tuberculosis. Methods The patients with tuberculosis treated with anti-tuberculosis therapy in our department from January 2012 to January 2013 were selected as the observation group， while no anti-tuberculosis treatment patients with tuberculosis during the same period were selected as the control group. The level of serum procalcitonin in the two groups before and after the treatment were compared and the anti-tuberculosis therapeutic effect difference of different levels of procalcitonin were analyzed. Results There was not significant difference in the level of serum procalcitonin before the treatment between the observation group and the control group. The levels of serum procalcitonin in the observation group after the treatment of 1 month， 3 months and 6 months decreased significantly（P

[Key words] Tuberculosis； Procalcitonin； Curative effect

肺结核是一种细胞介导的特异性免疫炎症，细胞免疫在其发生、发展及转归中扮演决定作用[1]。降钙素原是甲状腺滤泡旁C细胞分泌的糖蛋白，在炎症反应时显著升高，在炎症性疾病诊断、病情及预后评估中扮演重要作用[2]。研究表明，活动性肺结核和肺结核伴感染患者血清降钙素原均显著高于健康人[3]，但目前在降钙素原与抗结核疗效方面尚无相关研究。本研究检测结核病患者治疗前后血清降钙素原改变，分析其与疗效的关系，研究其在肺结核抗结核治疗疗效评估中的价值。