成骨诱导剂对拔牙创愈合的影响

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[摘要] 目的 探讨以明胶海绵为载体，地塞米松、维生素C和β-甘油磷酸钠组成的成骨诱导剂对拔牙创愈合和牙槽嵴形态改建的影响。方法 选用50只家兔，拔除双侧上颌第一前磨牙，右侧拔牙创内填入载有成骨诱导剂的明胶海绵，作为实验侧；左侧填入空载明胶海绵，作为对照侧。拔牙后第1、2、4、8、12周各处死10只动物，取双侧牙槽骨标本，拍摄X线片，并测量骨缺损区新骨密度；用组织学方法评价拔牙创愈合情况；并于12周时，测量拔牙区牙槽嵴高度吸收值。结果 X线片骨密度测量显示：术后2、4、8、12周，实验侧骨密度值均高于对照侧，差异有统计学意义（P

维生素C组成的成骨诱导剂能促进拔牙创愈合，加速成骨和骨改建。

[关键词] 成骨诱导剂； 拔牙创； 明胶海绵

[中图分类号] R 782.1 [文献标志码] A [doi] 10.3969/j.issn.1000-1182.2012.03.024

The effect of osteogenic inducer on healing of tooth extraction sockets Chen Junliang1, Shan Chuncheng1, He Yun2, Xia Delin2. （1. Dept. of Stomatology, The Yongchuan Affiliated Hospital, Chongqing Medical University, Chong-qing 402160, China; 2. Dept. of Oral and Maxillofacial Surgery, The Affiliated Hospital of Stomatology, Luzhou Medi-cal College, Luzhou 646000, China）

[Abstract] Objective To study the effect of osteogenic inducer（dexamethasone, β-sodium glycerophosphate and

Vitamin C） carried by gelatin sponge on healing and remodeling of tooth extraction sockets. Methods Fifty rabbits were selected. After extracting the first premolars of bilateral maxillary, the right side tooth extraction sockets were filled with gelatin sponge containing osteogenic inducer as experimental side, tooth extraction sockets on left side were filled with gelatin sponge as control. Every ten rabbits were executed at the end of 1, 2, 4, 8, 12 weeks after tooth extraction. Bone density was measured through digital X-ray images. The specimens were examined by histology． The absorption height of alveolar bone at 12 weeks was measured. Results X-ray measurement showed that the bone den-sity of experimental side was higher than that of control side at 2, 4, 8, 12 weeks, the difference had statistical sig-nificance（P

mental side was earlier than that in control side. The absorptional height of alveolar bone had significant difference between experimental side and control side（P

osteogenic inducer in tooth extraction sockets can promote the healing and new bone formation and prevent from al-veolar bone absorption.

[Key words] osteogenic inducer； tooth extraction socket； gelatin sponge

牙拔除后局部牙槽嵴缺乏牙齿的支持和功能性刺激而发生萎缩、吸收，给牙列修复和种植治疗带来了牙槽骨骨量不足的问题。学者们研究出多种预防牙槽嵴吸收的方法，但由于材料制取复杂、操作烦